At the conclusion of the course, the student will be able to:
* Describe the oxidative (Phase 1 and conjugative (Phase II) enzymes systems involved in human drug metabolism and disposition.
* Explain the various in vitro models used to evaluate the metabolism of a drug or new chemical entity and the pros and cons of each model system.
* Describe the factors involved in conducting in vivo drug metabolism studies and the strengths and limitations of in vivo studies.
* Explain the components used to predict in vivo drug disposition from in vitro data.
* Develop a presentation, using an example from the literature, describing a model study of human drug metabolism.
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