A- Caffeine clearance measured from saliva caffeine concentrations collected over 24 hours at each period of the
pregnancy and at post-partum (PP). Data are presented as a box and whisker plot where the line within the box represents the median value,
the range of the box represents from the 25th to the 75th percentile and the whiskers depict the range from the 10th to the
90th percentiles of the values. P values listed above each bar refer to comparison to the postpartum period.
Statistical significance determined at p < 0.05.
B- Mean (+- sd) percent change in CYP1A2 activity (as assessed by caffeine clearance) with subjects at each period of
pregnancy as compared to zero. I.e., the percent change for each individual at each period as compared to their respective
post-partum value. P values listed below each bar refer to comparison to the postpartum period. Statistical significance determined at p < 0.016.
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A- Urinary ratio of dextromethorphan/dextrorphan (DTM/DT) in a cumulative 24-hour urine sample at each
of the three periods of pregnancy and post-partum (PP). Data are presented as a box and whisker plot where the line
within the box represents the median value, the range of the box represents from the 25th to the 75th percentile and
the whiskers depict the range from the 10th to the 90th percentiles of the values. P values listed above each bar refer
to comparison to the postpartum period. Statistical significance determined at p < 0.05.
B - Mean (+- sd) percent change in CYP2D6 activity (as assessed by the DTM/DT ratio) with subjects at each period of
pregnancy as compared to zero. I.e., the percent change for each individual at each period as compared to their respective
post-partum value. P values listed above each bar refer to comparison to the postpartum period. Statistical significance
determined at p < 0.016.
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A - Urinary ratio of dextromethorphan/3-hydroxymorphinan (DTM/3-HM) in a cumulative 24-hour urine sample
at each of the three periods of pregnancy and at post-partum (PP). Data are presented as a box and whisker plot where
the line within the box represents the median value, the range of the box represents from the 25th to the 75th percentile
and the whiskers depict the range from the 10th to the 90th percentiles of the values. P values listed above each bar refer
to comparison to the postpartum period. Statistical significance determined at p < 0.05.
B - Mean (+- sd) percent change in CYP3A activity (as assessed by the DTM/DT ratio) with subjects at each
period of pregnancy as compared to zero . I.e., the percent change for each individual at each period as compared to
their respective post-partum value. P values listed above each bar refer to comparison to the postpartum period.
Statistical significance determined at p < 0.016.
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