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  • Genotype-Dependent Inhibition of CYP2C9
  • Genotype-Dependent CYP2C9 Switching
  • Mediated Activation of Naproxen Metabolism by CYP2C9
  • Increase in CYP2C9 Active Site Volume by the Effector, Dapsone
  • CYP1a2,CYP2D6,and CYP3A4 in Pregnancy

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Gannet PM, Miller L, Daft J, Locuson C, Tracy TS. Synthesis of deuterated naproxens. J Labelled Comp Radiopharm. 2007 December; 40(14):1272-1275.

Hodge LS, Tracy TS. Alterations in drug disposition during pregnancy: implications for drug therapy. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):557-71.

Wei L, Locuson CW, Tracy TS. Polymorphic variants of CYP2C9: mechanisms involved in reduced catalytic activity. Mol Pharmacol. 2007 Nov;72(5):1280-8.

Locuson CW, Tracy TS. Comparative modelling of the human UDP-glucuronosyltransferases: insights into structure and mechanism. Xenobiotica. 2007 Feb;37(2):155-68.

Locuson CW, Wienkers LC, Jones JP, Tracy TS. CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis. Drug Metab Dispos. 2007 Jul;35(7):1174-81.

Locuson CW, Gannett PM, Ayscue R, Tracy TS. Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9. J Med Chem. 2007 Mar 22;50(6):1158-65.

Locuson CW, Hutzler JM, Tracy TS. Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common. Drug Metab Dispos. 2007 Apr;35(4):614-22.

Zgheib NK, Frye RF, Tracy TS, Romkes M, Branch RA. Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity. Br J Clin Pharmacol. 2007 Apr;63(4):477-87.




Tracy TS. Atypical cytochrome p450 kinetics: implications for drug discovery. Drugs R D. 2006;7(6):349-63.

Kumar V, Wahlstrom JL, Rock DA, Warren CJ, Gorman LA, Tracy TS. CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug Metab Dispos. 2006 Dec;34(12):1966-75.

Locuson CW, Tracy TS. Identification of binding sites of non-I-helix water molecules in mammalian cytochromes P450. Drug Metab Dispos. 2006 Dec;34(12):1954-7.

Zgheib NK, Frye RF, Tracy TS, Romkes M, Branch RA. Validation of incorporating flurbiprofen into the Pittsburgh cocktail. Clin Pharmacol Ther. 2006 Sep;80(3):257-63.

Kumar V, Rock DA, Warren CJ, Tracy TS, Wahlstrom JL. Enzyme source effects on CYP2C9 kinetics and inhibition. Drug Metab Dispos. 2006 Nov;34(11):1903-8.

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